run any app off a USB drive?

Hey, guys, do you have the experience of running your daily used apps off a USB drive?

Which is I am now trying to do. But I find that only portable apps can be run like that.

while some apps like MS office are not portably available. How can I do that?

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updated

I suggest you use programs "light" if you use them with key ..

I intend to light such as mozilla, thinderbord, etc. ....
Programs such as large office programs is not recommended

You can watch the following websites
How to Run Software Directly Off a USB Flash Drive - wikiHow

PortableApps.com - Portable software for USB, portable and cloud drives